A New Biomarker of Fecal Bacteria for Non-Invasive Diagnosis of Colorectal Cancer.

ABSTRACT:

Background

The intestinal flora is correlated with the occurrence of colorectal cancer. We evaluate a new predictive model for the non-invasive diagnosis of colorectal cancer based on intestinal flora to verify the clinical application prospects of the intestinal flora as a new biomarker in non-invasive screening of colorectal cancer.

Methods

Subjects from two independent Asian cohorts (cohort I, consisting of 206 colorectal cancer and 112 healthy subjects; cohort II, consisting of 67 colorectal cancer and 54 healthy subjects) were included. A probe-based duplex quantitative PCR (qPCR) determination was established for the quantitative determination of candidate bacterial markers.

Results

We screened through the gutMEGA database to identify potential non-invasive biom

SUBMITTER: Yao Y 

PROVIDER: S-EPMC8719628 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature