Pallido-putaminal connectivity predicts outcomes of deep brain stimulation for cervical dystonia.

ABSTRACT: Cervical dystonia is a non-degenerative movement disorder characterized by dysfunction of both motor and sensory cortico-basal ganglia networks. Deep brain stimulation targeted to the internal pallidum is an established treatment, but its specific mechanisms remain elusive, and response to therapy is highly variable. Modulation of key dysfunctional networks via axonal connections is likely important. Fifteen patients underwent preoperative diffusion-MRI acquisitions and then progressed to bilateral deep brain stimulation targeting the posterior internal pallidum. Severity of disease was assessed preoperatively and later at follow-up. Scans were used to generate tractography-derived connectivity estimates between the bilateral regions of stimulation and relevant structures. Connectivity to

SUBMITTER: Raghu ALB 

PROVIDER: S-EPMC8719844 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature