Bedside determination of microcirculatory oxygen delivery and uptake: a prospective observational clinical study for proof of principle.

ABSTRACT: Assessment of microcirculatory functional capacity is considered to be of prime importance for therapy guidance and outcome prediction in critically ill intensive care patients. Here, we show determination of skin microcirculatory oxygen delivery and consumption rates to be a feasible approach at the patient's bedside. Real time laser-doppler flowmetry (LDF) and white light spectrophotometry (WLS) were used for assessment of thenar skin microperfusion, regional Hb and postcapillary venous oxygen saturation before and after forearm ischemia. Adapted Fick's principle equations allowed for calculation of microcirculatory oxygen delivery and uptake. Patient groups with expected different microcirculatory status were compared [control (n = 20), sepsis-1/2 definition criteria identified SIRS (n 

SUBMITTER: Sturm T 

PROVIDER: S-EPMC8720096 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature