Visuomotor brain network activation and functional connectivity among individuals with autism spectrum disorder.

ABSTRACT: Sensorimotor abnormalities are common in autism spectrum disorder (ASD) and predictive of functional outcomes, though their neural underpinnings remain poorly understood. Using functional magnetic resonance imaging, we examined both brain activation and functional connectivity during visuomotor behavior in 27 individuals with ASD and 30 typically developing (TD) controls (ages 9-35 years). Participants maintained a constant grip force while receiving visual feedback at three different visual gain levels. Relative to controls, ASD participants showed increased force variability, especially at high gain, and reduced entropy. Brain activation was greater in individuals with ASD than controls in supplementary motor area, bilateral superior parietal lobules, and contralateral middle frontal gyr

SUBMITTER: Lepping RJ 

PROVIDER: S-EPMC8720186 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature