Mental health in the UK Biobank: A roadmap to self-report measures and neuroimaging correlates.

ABSTRACT: The UK Biobank (UKB) is a highly promising dataset for brain biomarker research into population mental health due to its unprecedented sample size and extensive phenotypic, imaging, and biological measurements. In this study, we aimed to provide a shared foundation for UKB neuroimaging research into mental health with a focus on anxiety and depression. We compared UKB self-report measures and revealed important timing effects between scan acquisition and separate online acquisition of some mental health measures. To overcome these timing effects, we introduced and validated the Recent Depressive Symptoms (RDS-4) score which we recommend for state-dependent and longitudinal research in the UKB. We furthermore tested univariate and multivariate associations between brain imaging-derived phen

SUBMITTER: Dutt RK 

PROVIDER: S-EPMC8720192 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature