Characterization of tumor-associated macrophages in prostate cancer transgenic mouse models.

ABSTRACT:

Background

Tumor-associated macrophages (TAMs) are critical components of the tumor microenvironment (TME) in prostate cancer. Commonly used orthotopic models do not accurately reflect the complete TME of a human patient or the natural initiation and progression of a tumor. Therefore, genetically engineered mouse models are essential for studying the TME as well as advancing TAM-targeted therapies. Two common transgenic (TG) models of prostate cancer are Hi-Myc and transgenic adenocarcinoma of the mouse prostate (TRAMP), but the TME and TAM characteristics of these models have not been well characterized.

Methods

To advance the Hi-Myc and TRAMP models as tools for TAM studies, macrophage infiltration and characteristics were assessed using histopathologic, flow cytometric, a

SUBMITTER: de Groot AE 

PROVIDER: S-EPMC8720375 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature