Jekyll and Hyde: Activating the Hypoxic Translational Machinery.

ABSTRACT: Global translational remodeling has emerged as a principal mechanism of biological adaptation. Oxygen deficiency (hypoxia) disables the basal protein synthesis machinery ('Jekyll') and activates a hypoxic translational architecture ('Hyde') to drive translatome remodeling. Independent from mRNA-level fluctuations, this newer paradigm modernizes a field traditionally dominated by the hypoxia-inducible factor (HIF) transcriptional program.

SUBMITTER: Ho JJD 

PROVIDER: S-EPMC8720417 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature