Ontology highlight
ABSTRACT:
SUBMITTER: Feldman J
PROVIDER: S-EPMC8720485 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Feldman Jared J Bals Julia J Altomare Clara G CG St Denis Kerri K Lam Evan C EC Hauser Blake M BM Ronsard Larance L Sangesland Maya M Moreno Thalia Bracamonte TB Okonkwo Vintus V Hartojo Nathania N Balazs Alejandro B AB Bajic Goran G Lingwood Daniel D Schmidt Aaron G AG
Science immunology 20211210 66
Initial exposure to a pathogen elicits an adaptive immune response to control and eradicate the threat. Interrogating the abundance and specificity of the naive B cell repertoire drives understanding of how to mount protective responses. Here, we isolated naive B cells from eight seronegative human donors targeting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor binding domain (RBD). Single-cell B cell receptor (BCR) sequencing identified diverse gene usage and no restr ...[more]