Role of progenitor cell marker CD133 in supporting diagnosis of collapsing glomerulopathy.

ABSTRACT:

Purpose

A previous immunofluorescent study suggests that, in collapsing glomerulopathy, most hyperplastic podocytes that stained positively for a progenitor cell marker CD133 are derived from CD133 + parietal epithelial cells. In pathology practice, not all renal biopsies with collapsing glomerulopathy show the typical morphologic features for this entity, which include florid podocyte hyperplasia, collapsing glomerular capillary loops, and cystic tubular dilation. This study was made to determine if CD133 staining using an immunohistochemical method can be used to confirm hyperplastic podocytes and identify extensive acute tubular injury in collapsing glomerulopathy.

Methods

Twenty-one collapsing glomerulopathy biopsies were stained for CD133 and compared with 15 biopsies w

SUBMITTER: Xiao AY 

PROVIDER: S-EPMC8720538 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature