Transcriptomic profiling of peroxisome-related genes reveals a novel prognostic signature in hepatocellular carcinoma.

ABSTRACT: Emerging evidence suggests that peroxisomes play a role in the regulation of tumorigenesis and cancer progression. However, the prognostic value of peroxisome-related genes has been rarely investigated. This study aimed to establish a peroxisome-related gene signature for overall survival (OS) prediction in patients with hepatocellular carcinoma (HCC). First, univariate Cox regression analysis was employed to identify prognostic peroxisome-related genes in The Cancer Genome Atlas liver cancer cohort, and least absolute shrinkage and selection operator Cox regression analysis was used to construct a 10-gene signature. The risk score based on the signature was positively correlated with poor prognosis (HR = 4.501, 95% CI = 3.021-6.705, P = 1.39e-13). Second, multivariate Cox regressio

SUBMITTER: Qiu L 

PROVIDER: S-EPMC8720664 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature