Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy.

ABSTRACT: Age-related macular degeneration (AMD) is a complex eye disorder and is the leading cause of incurable blindness worldwide in the elderly. Clinically, AMD initially affects the central area of retina known as the macula and it is classified as early stage to late stage (advanced AMD). The advanced AMD is classified into the nonexudative or atrophic form (dry AMD) and the exudative or neovascular form (wet AMD). More severe vision loss is typically associated with the wet form. Multiple genetic factors, lipid metabolism, oxidative stress and aging, play a role in the etiology of AMD. Dysregulation in genetic to AMD is established to 46%-71% of disease contribution, with CFH and ARMS2/HTRA1 to be the two most notable risk loci among the 103 identified AMD associated loci so far

SUBMITTER: Deng Y 

PROVIDER: S-EPMC8720701 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature