Increased Platelet-CD4⁺ T Cell Aggregates Are Correlated With HIV-1 Permissiveness and CD4⁺ T Cell Loss.

ABSTRACT: Chronic HIV-1 infection is associated with persistent inflammation, which contributes to disease progression. Platelet-T cell aggregates play a critical role in maintaining inflammation. However, the phenotypic characteristics and clinical significance of platelet-CD4⁺ T cell aggregates remain unclear in different HIV-infected populations. In this study, we quantified and characterized platelet-CD4⁺ T cell aggregates in the peripheral blood of treatment-naïve HIV-1-infected individuals (TNs), immunological responders to antiretroviral therapy (IRs), immunological non-responders to antiretroviral therapy (INRs), and healthy controls (HCs). Flow cytometry analysis and immunofluorescence microscopy showed increased platelet-CD4 ⁺ T cell aggregate format

SUBMITTER: Dai XP 

PROVIDER: S-EPMC8720770 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature