Pharmacokinetic profile of sildenafil citrate in healthy Middle Eastern Males: Comparison with other ethnicities.

ABSTRACT:

Aim

1) To investigate the pharmacokinetic profile of sildenafil citrate in Middle Eastern males and, 2) To highlight the impact of ethnicity on its pharmacokinetics parameters through comparing Middle Eastern data to the data estimated from different ethnic groups.

Method

The study was conducted on 24 Middle Eastern healthy male volunteers. Pharmacokinetic data including C_max, T_max, t_1/2, AUC_0-t, AUC_0-∞ were estimated from blood samples collected at several time points within 24 h post-administration of a single 100-mg tablet of sildenafil citrate (Viagra®). Pharmacokinetic data of sildenafil generic 100-mg tablet (product B) was determined in the volunteers using the same analytical method. Pharmacokinetic data of other

SUBMITTER: Alwhaibi A 

PROVIDER: S-EPMC8720797 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature