A Novel Scoring System Based on Oxford Classification Indicating Steroid Therapy Use for IgA Nephropathy.

ABSTRACT:

Introduction

The usefulness of the Oxford classification (MEST-C score) for deciding the management approach for IgA nephropathy (IgAN) remains unclear.

Methods

Effects of steroid therapy on the long-term prognosis for all 858 patients with IgAN and patients classified according to each MEST-C score were evaluated using Kaplan-Meier and Cox regression analyses. Steroid responder score (SRS) and steroid nonresponder score (SNRS) were determined using individual pathology scores when steroids were found to be independently associated, or not, with clinical benefits. In addition, the effects of steroid therapy according to the total SRS/SNRS were analyzed.

Results

Steroid therapy improved the 20-year renal survival rates of patients with IgAN after matching (steroids[+]

SUBMITTER: Itami S 

PROVIDER: S-EPMC8720825 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature