Thromboxane Mobilizes Insect Blood Cells to Infection Foci.

ABSTRACT: Innate immune responses are effective for insect survival to defend against entomopathogens including a fungal pathogen, Metarhizium rileyi, that infects a lepidopteran Spodoptera exigua. In particular, the fungal virulence was attenuated by cellular immune responses, in which the conidia were phagocytosed by hemocytes (insect blood cells) and hyphal growth was inhibited by hemocyte encapsulation. However, the chemokine signal to drive hemocytes to the infection foci was little understood. The hemocyte behaviors appeared to be guided by a Ca²⁺ signal stimulating cell aggregation to the infection foci. The induction of the Ca²⁺ signal was significantly inhibited by the cyclooxygenase (COX) inhibitor. Under the inhibitory condition, the addition of thrombo

SUBMITTER: Roy MC 

PROVIDER: S-EPMC8720849 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature