The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions.
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ABSTRACT: This review addresses pharmacological, structural and functional relationships among H2-histamine receptors and H1-histamine receptors in the mammalian heart. The role of both receptors in the regulation of force and rhythm, including their electrophysiological effects on the mammalian heart, will then be discussed in context. The potential clinical role of cardiac H2-histamine-receptors in cardiac diseases will be examined. The use of H2-histamine receptor agonists to acutely increase the force of contraction will be discussed. Special attention will be paid to the potential role of cardiac H2-histamine receptors in the genesis of cardiac arrhythmias. Moreover, novel findings on the putative role of H2-histamine receptor an
SUBMITTER: Neumann J
PROVIDER: S-EPMC8720924 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
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