Protease-Activated Receptors - Key Regulators of Inflammatory Bowel Diseases Progression.

ABSTRACT: The pathogenesis and course of inflammatory bowel diseases are related to both immune system disorders and dysfunction of colon permeability. Moreover, co-existing diseases in patients with Crohn's disease and ulcerative colitis are identified. Currently, there are some therapeutic strategies that affect the function of cytokine/s causing inflammation in the intestinal wall. However, additional approaches which target other components of inflammatory bowel diseases pathogenesis are still needed. Accumulating evidence suggests that proteases and protease-activated receptors seem to be responsible for colitis progression. Experimental and observational studies showed alteration of protease-activated receptors expression in the colon of patients with Crohn's disease and ulcerative colitis. Fu

SUBMITTER: Jacenik D 

PROVIDER: S-EPMC8721023 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature