Genetic Ablation of the Mitochondrial Calcium Uniporter (MCU) Does not Impair T Cell-Mediated Immunity In Vivo.

ABSTRACT: T cell activation and differentiation is associated with metabolic reprogramming to cope with the increased bioenergetic demand and to provide metabolic intermediates for the biosynthesis of building blocks. Antigen receptor stimulation not only promotes the metabolic switch of lymphocytes but also triggers the uptake of calcium (Ca²⁺) from the cytosol into the mitochondrial matrix. Whether mitochondrial Ca²⁺ influx through the mitochondrial Ca²⁺ uniporter (MCU) controls T cell metabolism and effector function remained, however, enigmatic. Using mice with T cell-specific deletion of MCU, we here show that genetic inactivation of mitochondrial Ca²⁺ uptake increased cytosolic Ca²⁺ levels following antigen receptor stimulation and store-o

SUBMITTER: Wu H 

PROVIDER: S-EPMC8721163 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature