A Novel Hybrid Logic-ODE Modeling Approach to Overcome Knowledge Gaps.

ABSTRACT: Mathematical modeling allows using different formalisms to describe, investigate, and understand biological processes. However, despite the advent of high-throughput experimental techniques, quantitative information is still a challenge when looking for data to calibrate model parameters. Furthermore, quantitative formalisms must cope with stiffness and tractability problems, more so if used to describe multicellular systems. On the other hand, qualitative models may lack the proper granularity to describe the underlying kinetic processes. We propose a hybrid modeling approach that integrates ordinary differential equations and logical formalism to describe distinct biological layers and their communication. We focused on a multicellular system as a case study by applying the hybrid formal

SUBMITTER: Selvaggio G 

PROVIDER: S-EPMC8721169 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature