H₂S donating corticosteroids: Design, synthesis and biological evaluation in a murine model of asthma.

ABSTRACT:

Introduction

Hydrogen sulfide (H₂S) is a fundamental biological endogenous gas-mediator in the respiratory system. It regulates pivotal patho-physiological processes such as oxidative stress, pulmonary circulation, airway tone and inflammation.

Objectives

We herein describe the design and synthesis of molecular hybrids obtained by the condensation of several corticosteroids with different hydrogen sulfide releasing moieties.

Methods

All the molecules are characterized for their ability to release H₂S both via amperometric approach and using a fluorescent probe. The chemical stability of the newly synthesized hybrid molecules has been investigated at differing pH values and in human serum.

Results

Prednisone-TBZ hybrid (compound 7) w

SUBMITTER: Corvino A 

PROVIDER: S-EPMC8721254 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature