An altered microbiota pattern precedes Type 2 diabetes mellitus development: From the CORDIOPREV study.

ABSTRACT:

Introduction

A distinctive gut microbiome have been linked to type 2 diabetes mellitus (T2DM).

Objectives

We aimed to evaluate whether gut microbiota composition, in addition to clinical biomarkers, could improve the prediction of new incident cases of diabetes in patients with coronary heart disease.

Methods

All the patients from the CORDIOPREV (Clinical Trials.gov.Identifier: NCT00924937) study without T2DM at baseline were included (n = 462). Overall, 107 patients developed it after a median of 60 months. The gut microbiota composition was determined by 16S rRNA gene sequencing and predictive models were created using hold-out method.

Results

A gut microbiota profile associated with T2DM development was determined through a microbiome-based predictive model.

SUBMITTER: Vals-Delgado C 

PROVIDER: S-EPMC8721255 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature