The link between deacetylation and hepatotoxicity induced by exposure to hexavalent chromium.

ABSTRACT:

Introduction

Hexavalent chromium (Cr(VI)), one of the toxic heavy metals, poses a serious threat to human and animal health. Protein acetylation regulates the structure and function of most proteins in a variety of ways. However, the hepatotoxicity of Cr(VI) and whether it is related to deacetylation remains largely unknown.

Objectives

We aimed to explore the link between the deacetylation of silent information regulator two ortholog 1 (Sirt1) and hepatotoxicity induced by Cr(VI) exposure, and to better clarify the biological mechanism of liver injury induced by Cr(VI).

Methods

We established a model of liver injury of K₂Cr₂O₇ by injecting rats intraperitoneally for 35 days continuously and adding resveratrol (Res) to further explore t

SUBMITTER: Yang Q 

PROVIDER: S-EPMC8721258 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature