Weighted pseudo-values for partly unobserved group membership in paediatric stem cell transplantation studies.

ABSTRACT: Generalised pseudo-values have been suggested to evaluate the impact of allogeneic stem cell transplantation on childhood leukaemia. The approach compares long-term survival of two cohorts defined by the availability or non-availability of suitable donors for stem cell transplantation. A patient's cohort membership becomes known only after completed donor search with or without an identified donor. If a patient suffers an event during donor search, stem cell transplantation will no longer be indicated. In such a case, donor search will be ceased and cohort membership will remain unknown. The generalised pseudo-values approach considers donor identification as binary time-dependent covariate and uses inverse-probability-of-censoring weighting to adjust for non-identified donors. The approac

SUBMITTER: Mittlbock M 

PROVIDER: S-EPMC8721556 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature