Postseptic Cognitive Impairment and Expression of APOE in Peripheral Blood: The Cognition After SepsiS (CASS) Observational Pilot Study.

ABSTRACT:

Background

Cognitive impairment after sepsis is an important clinical problem. Determinants of postseptic cognitive impairment are not well understood. We thus undertook a systems biology approach to exploring a possible role for apolipoprotein E (APOE) in postseptic cognitive impairment.

Design

Prospective, observational cohort.

Setting

Intermountain Medical Center, a tertiary referral center in Utah.

Patients/participants

Patients with sepsis admitted to study intensive care units.

Interventions

None.

Methods

We obtained peripheral blood for deep sequencing of RNA and followed up survivors at 6 months with a battery of cognitive instruments. We defined cognitive impairment based on the 6-month Hayling test of executive function. In our primary a

SUBMITTER: Brown SM 

PROVIDER: S-EPMC8721590 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature