Effects of incretin-based therapies on β-cell function in type 1 diabetes mellitus: a systematic review and meta-analysis.

ABSTRACT:

Aim

To assess the effects of incretin-based therapies on β-cell function in patients with type 1 diabetes mellitus (T1DM).

Methods

We searched the PubMed, Cochrane Library, Embase, and Web of Knowledge databases for eligible randomized clinical trials published up to July 2021. The inclusion criteria were patients with T1DM or latent autoimmune diabetes in adults, patients treated with dipeptidyl peptidase-4 inhibitors or glucagon like peptide-1 receptor agonists, and outcomes included one of the following: fasting plasma glucose, fasting C-peptide, postprandial C-peptide, C-peptide area under the curve (AUC), homeostasis model assessment for β cell function, and insulin resistance. The effects were analyzed using a random effect model with STATA 11.0.

Results

Eight t

SUBMITTER: Wu Y 

PROVIDER: S-EPMC8721710 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature