Demographic Influences on the Relationship Between Fatigue and Quality of Life in Parkinson's Disease.

ABSTRACT:

Background

Fatigue has a major impact on health-related quality of life (HR-QOL) in Parkinson's disease (PD).

Objectives

To determine whether demographic characteristics modify the relationship between fatigue and HR-QOL.

Methods

Patients with PD in the Fox Insight study completed the Parkinson Fatigue Scale (PFS-16) and Geriatric Depression Scale (GDS-15). Linear regression examined the relationship between the PFS-16 and Parkinson Disease Quality of Life, as modified by age, sex, and GDS-15.

Results

A total of 1029 participants (44% female, mean age 67.4 years, and mean disease duration 4.6 years) were included in this analysis. Multivariable regression modeling demonstrated a negative effect modification for age (β = -0.07, P < 0.001) and a positive e

SUBMITTER: Mantri S 

PROVIDER: S-EPMC8721823 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature