GPi-DBS for KMT2B-Associated Dystonia: Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Early evidence suggests good response to pallidal deep brain stimulation (DBS) in DYT-KMT2B.

Objectives

We aimed to conduct a systematic review and meta-analysis to assess outcomes and identify predictors of good outcome following GPi-DBS in DYT-KMT2B.

Methods

We searched MEDLINE, Cochrane and MDS-abstracts databases using the MeSH terms "KMT2B and DYT28". We included studies that reported objective outcomes following GPi-DBS in DYT-KMT2B. The BFMDRS-M (Burke-Fahn-Marsden Dystonia Rating Scale- Movement) total scores pre- and post-surgery were used to quantify outcomes. We calculated pooled effects using a random effects meta-analysis and used meta-regression to identify potential effect modifiers. Multiple linear regression usin

SUBMITTER: Rajan R 

PROVIDER: S-EPMC8721835 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature