Integrative analysis reveals mouse strain-dependent responses to acute ozone exposure associated with airway macrophage transcriptional activity.

ABSTRACT: Acute ozone (O₃) exposure is associated with multiple adverse cardiorespiratory outcomes, the severity of which varies across individuals in human populations and inbred mouse strains. However, molecular determinants of response, including susceptibility biomarkers that distinguish who will develop severe injury and inflammation, are not well characterized. We and others have demonstrated that airway macrophages (AMs) are an important resident immune cell type that are functionally and transcriptionally responsive to O₃ inhalation. Here, we sought to explore influences of strain, exposure, and strain-by-O₃ exposure interactions on AM gene expression and identify transcriptional correlates of O₃-induced inflammation and injury across six mouse str

SUBMITTER: Tovar A 

PROVIDER: S-EPMC8721896 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature