Salivary anti-nuclear antibody (ANA) mirrors serum ANA in systemic lupus erythematosus.

ABSTRACT:

Objectives

To assay salivary anti-nuclear antibody (ANA) and its isotypes in patients with systemic lupus erythematosus (SLE) and to investigate relevant clinical associations.

Methods

Saliva samples were collected from SLE patients and assayed for salivary ANA using immunofluorescence (IF). Isotypes of salivary ANA, including IgG-ANA, IgA-ANA, and IgM-ANA, were quantified using enzyme-linked immunosorbent assay. The correlations between clinical parameters and levels of salivary ANA and isotypes were evaluated.

Results

Salivary ANA IF intensities were significantly higher in SLE patients than in healthy controls, irrespective of SLE patient disease activity, and strongly correlated with serum ANA titers. Salivary ANA was detected in 67.14% of SLE patients and 10.00%

SUBMITTER: Zhang T 

PROVIDER: S-EPMC8721993 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature