Induction of m⁶A methylation in adipocyte exosomal LncRNAs mediates myeloma drug resistance.

ABSTRACT:

Background

Therapeutic resistance occurs in most patients with multiple myeloma (MM). One of the key mechanisms for MM drug resistance comes from the interaction between MM cells and adipocytes that inhibits drug-induced apoptosis in MM cells; MM cells reprogram adipocytes to morph into different characterizations, including exosomes, which are important for tumor-stroma cellular communication. However, the mechanism by which exosomes mediate the cellular machinery of the vicious cycle between MM cells and adipocytes remains unclear.

Methods

Adipocytes were either isolated from bone marrow aspirates of healthy donors or MM patients or derived from mesenchymal stem cells. Co-culturing normal adipocytes with MM cells was used to generate MM-associated adipocytes. Exosomes were

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8722039 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature