Integrative analysis of CRISPR screening data uncovers new opportunities for optimizing cancer immunotherapy.

ABSTRACT:

Background

In recent years, the application of functional genetic immuno-oncology screens has showcased the striking ability to identify potential regulators engaged in tumor-immune interactions. Although these screens have yielded substantial data, few studies have attempted to systematically aggregate and analyze them.

Methods

In this study, a comprehensive data collection of tumor immunity-associated functional screens was performed. Large-scale genomic data sets were exploited to conduct integrative analyses.

Results

We identified 105 regulator genes that could mediate resistance or sensitivity to immune cell-induced tumor elimination. Further analysis identified MON2 as a novel immune-oncology target with considerable therapeutic potential. In addition, based on

SUBMITTER: Li Y 

PROVIDER: S-EPMC8722047 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature