Increased expression of six-large extracellular vesicle-derived miRNAs signature for nonvalvular atrial fibrillation.

ABSTRACT:

Backgrounds

Non-valvular atrial fibrillation (AF) is the most common type of cardiac arrhythmia. AF is caused by electrophysiological abnormalities and alteration of atrial tissues, which leads to the generation of abnormal electrical impulses. Extracellular vesicles (EVs) are membrane-bound vesicles released by all cell types. Large EVs (lEVs) are secreted by the outward budding of the plasma membrane during cell activation or cell stress. lEVs are thought to act as vehicles for miRNAs to modulate cardiovascular function, and to be involved in the pathophysiology of cardiovascular diseases (CVDs), including AF. This study identified lEV-miRNAs that were differentially expressed between AF patients and non-AF controls.

Methods

lEVs were isolated by differential centrifugatio

SUBMITTER: Siwaponanan P 

PROVIDER: S-EPMC8722074 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature