Latent class analysis of 216 patients with adult-onset Still's disease.

ABSTRACT:

Background

Adult-onset Still's disease (AOSD) is a rare systemic autoinflammatory disease which encompasses patients with heterogenous presentation and a wide range of clinical courses. In this study, we aimed to identify potential subgroups of AOSD and reveal risk factors for relapse.

Methods

We included a total of 216 AOSD patients who received treatment in nine hospitals between 2000 and 2019. All patients fulfilled the Yamaguchi classification criteria. We retrospectively collected information about baseline characteristics, laboratory tests, treatment, relapse, and death. We performed latent class analysis and time-to-event analysis for relapse using the Cox proportional hazard model.

Results

The median age at disease onset was 51.6 years. The median follow-up pe

SUBMITTER: Sugiyama T 

PROVIDER: S-EPMC8722082 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature