Association of immunity markers with the risk of incident frailty: the Rugao longitudinal aging study.

ABSTRACT:

Background

The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) are readily available circulatory immunity markers that are associated with components of frailty. However, few studies have investigated the relationship between these immunity markers and frailty, and it remains unknown whether they are predictive of incident frailty in older adults in general. Hence, we aimed to examine the association of these immunity markers with the risk of incident frailty.

Results

Overall, 1822 older adults (mean age was 78.03 ± 4.46 years) were included in the Rugao Longitudinal Aging Study. NLR, PLR and SII were calculated from blood cell counts. The frailty definition was based on the Fried phenotype. At baseline, 2

SUBMITTER: Zhang H 

PROVIDER: S-EPMC8722120 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature