The frequency of the known mitochondrial variants associated with drug-induced toxicity in a Korean population.

ABSTRACT:

Background

Few studies have annotated the whole mitochondrial DNA (mtDNA) genome associated with drug responses in Asian populations. This study aimed to characterize mtDNA genetic profiles, especially the distribution and frequency of well-known genetic biomarkers associated with diseases and drug-induced toxicity in a Korean population.

Method

Whole mitochondrial genome was sequenced for 118 Korean subjects by using a next-generation sequencing approach. The bioinformatic pipeline was constructed for variant calling, haplogroup classification and annotation of mitochondrial mutation.

Results

A total of 681 variants was identified among all subjects. The MT-TRNP gene and displacement loop showed the highest numbers of variants (113 and 74 variants, respectively). The

SUBMITTER: Pham VH 

PROVIDER: S-EPMC8722126 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature