Ca_vβ surface charged residues contribute to the regulation of neuronal calcium channels.

ABSTRACT: Voltage-gated calcium channels are essential regulators of brain function where they support depolarization-induced calcium entry into neurons. They consist of a pore-forming subunit (Ca_vα₁) that requires co-assembly with ancillary subunits to ensure proper functioning of the channel. Among these ancillary subunits, the Ca_vβ plays an essential role in regulating surface expression and gating of the channels. This regulation requires the direct binding of Ca_vβ onto Ca_vα₁ and is mediated by the alpha interacting domain (AID) within the Ca_vα₁ subunit and the α binding pocket (ABP) within the Ca_vβ subunit. However, additional interactions between Ca_vα₁ and Ca_vβ ha

SUBMITTER: Tran-Van-Minh A 

PROVIDER: S-EPMC8722133 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature