Compression enhances invasive phenotype and matrix degradation of breast Cancer cells via Piezo1 activation.

ABSTRACT:

Background

Uncontrolled growth in solid breast cancer generates mechanical compression that may drive the cancer cells into a more invasive phenotype, but little is known about how such compression affects the key events and corresponding regulatory mechanisms associated with invasion of breast cancer cells including cellular behaviors and matrix degradation.

Results

Here we show that compression enhanced invasion and matrix degradation of breast cancer cells. We also identified Piezo1 as the putative mechanosensitive cellular component that transmitted compression to not only enhance the invasive phenotype, but also induce calcium influx and downstream Src signaling. Furthermore, we demonstrated that Piezo1 was mainly localized in caveolae, and both Piezo1 expression and co

SUBMITTER: Luo M 

PROVIDER: S-EPMC8722159 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature