Intestinal dysbiosis featuring abundance of Streptococcus associates with Henoch-Schonlein purpura nephritis (IgA vasculitis with nephritis) in adult.

ABSTRACT:

Background

The pathogenesis of Henoch-Schönlein purpura nephritis (HSPN) is closely associated with mucosal infection. But whether intestinal microbiota dysbiosis plays a role in it is not clear.

Methods

A total of 52 participants including 26 HSPN patients and 26 healthy controls were included. By using 16S ribosomal RNA gene sequencing, the intestinal microbiota composition between HSPN and healthy controls was compared. The diagnostic potency was evaluated by Receiver operating characteristic (ROC) with area under curves (AUC). Meanwhile, correlation analysis was also performed.

Results

The lower community richness and diversity of fecal microbiota was displayed in HSPN patients and the structure of gut microbiota was remarkedly different. A genus-level comparison

SUBMITTER: Tan J 

PROVIDER: S-EPMC8722171 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature