Selective internal radiation therapy for hepatic metastases of uveal melanoma: a systematic review.

ABSTRACT:

Objective

Uveal melanoma (UM) commonly metastasizes to the liver. Treatment usually consists of liver-directed therapies, such as selective internal radiation therapy (SIRT). This review aimed to assess the effectiveness and safety of SIRT for hepatic metastases from UM.

Methods

The study protocol is available at OSF (https://osf.io/vhyct/). EMBASE and MEDLINE were searched until July 2020, using terms related to SIRT and hepatic metastases from UM. Studies reporting outcomes of SIRT in patients with UM and at least one hepatic metastasis were included. Data on overall survival (OS), hepatic progression free survival (hPFS) or tumor response were collected. The Newcastle-Ottawa Scale (NOS) was used to assess risk of bias.

Results

11 studies were included, reporting ou

SUBMITTER: Alexander H 

PROVIDER: S-EPMC8722257 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature