Cytochrome b561 Serves as a Potential Prognostic Biomarker and Target for Breast Cancer.

ABSTRACT:

Purpose

Cytochrome b561 (CYB561) is a transmembrane protein and participates in ascorbate recycling and iron homeostasis. However, its role in breast cancer remains unclear.

Patients and methods

In this study, we explored the expression pattern and prognostic value of CYB561 in breast cancer through The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), PrognoScan and Kaplan-Meier Plotter and confirmed its mRNA expression in human breast cell lines. LinkedOmics, Metascape and Gene Expression Profiling Interactive Analysis (GEPIA2) databases were applied to investigate the co-expression genes and construct microRNA (miRNA) networks associated with CYB561. The correlations between CYB561 and immune infiltration cells and genes were also illustrated.

Results

The

SUBMITTER: Yang X 

PROVIDER: S-EPMC8722309 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature