Association between bone mineral metabolism and vascular calcification in end-stage renal disease.

ABSTRACT:

Background

Development of vascular calcification is accelerated in patients with end-stage renal disease. In addition to traditional risk factors of cardiovascular disease (CVD) abnormal bone and mineral metabolism together with many other factors contribute to the excess cardiovascular burden in patients on dialysis. Aortic calcification score and coronary calcification score are predictive of CVD and mortality. The aim of this study was to evaluate the possible relationship between arterial calcification and bone metabolism.

Methods

Thirty two patients on dialysis were included. All patients underwent a bone biopsy to assess bone histomorphometry and a ¹⁸F-NaF PET scan. Fluoride activity was measured in the lumbar spine (L1 - L4) and at the anterior iliac crest.

SUBMITTER: Aaltonen L 

PROVIDER: S-EPMC8722315 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature