Spatial N-glycomics of the human aortic valve in development and pediatric endstage congenital aortic valve stenosis.

ABSTRACT: Congenital aortic valve stenosis (AS) progresses as an obstructive narrowing of the aortic orifice due to deregulated extracellular matrix (ECM) production by aortic valve (AV) leaflets and leads to heart failure with no effective therapies. Changes in glycoprotein and proteoglycan distribution are a hallmark of AS, yet valvular carbohydrate content remains virtually uncharacterized at the molecular level. While almost all glycoproteins clinically linked to stenotic valvular modeling contain multiple sites for N-glycosylation, there are very few reports aimed at understanding how N-glycosylation contributes to the valve structure in disease. Here, we tested for spatial localization of N-glycan structures within pediatric congenital aortic valve stenosis. The study was done on valvular tiss

SUBMITTER: Angel PM 

PROVIDER: S-EPMC8722354 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature