Synaptic protein interaction networks encode experience by assuming stimulus-specific and brain-region-specific states.

ABSTRACT: A core network of widely expressed proteins within the glutamatergic post-synapse mediates activity-dependent synaptic plasticity throughout the brain, but the specific proteomic composition of synapses differs between brain regions. Here, we address the question, how does proteomic composition affect activity-dependent protein-protein interaction networks (PINs) downstream of synaptic activity? Using quantitative multiplex co-immunoprecipitation, we compare the PIN response of in vivo or ex vivo neurons derived from different brain regions to activation by different agonists or different forms of eyeblink conditioning. We report that PINs discriminate between incoming stimuli using differential kinetics of overlapping and non-overlapping PIN parameters. Further, these "molecular logic rul

SUBMITTER: Lautz JD 

PROVIDER: S-EPMC8722361 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature