A proteomics informed by transcriptomics insight into the proteome of Ornithodoros erraticus adult tick saliva.

ABSTRACT:

Background

The argasid tick Ornithodoros erraticus is the main vector of tick-borne human relapsing fever (TBRF) and African swine fever (ASF) in the Mediterranean Basin. The prevention and control of these diseases would greatly benefit from the elimination of O. erraticus populations, and anti-tick vaccines are envisaged as an effective and sustainable alternative to chemical acaricide usage for tick control. Ornithodoros erraticus saliva contains bioactive proteins that play essential functions in tick feeding and host defence modulation, which may contribute to host infection by tick-borne pathogens. Hence, these proteins could be candidate antigen targets for the development of vaccines aimed at the control and prevention of O. erraticus infestations and the diseases this tick

SUBMITTER: Perez-Sanchez R 

PROVIDER: S-EPMC8722417 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature