Ontology highlight
ABSTRACT:
SUBMITTER: Munjal A
PROVIDER: S-EPMC8722442 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Munjal Akankshi A Hannezo Edouard E Tsai Tony Y-C TY Mitchison Timothy J TJ Megason Sean G SG
Cell 20211201 26
How tissues acquire complex shapes is a fundamental question in biology and regenerative medicine. Zebrafish semicircular canals form from invaginations in the otic epithelium (buds) that extend and fuse to form the hubs of each canal. We find that conventional actomyosin-driven behaviors are not required. Instead, local secretion of hyaluronan, made by the enzymes uridine 5'-diphosphate dehydrogenase (ugdh) and hyaluronan synthase 3 (has3), drives canal morphogenesis. Charged hyaluronate polyme ...[more]