A systematic review of phage therapy applied to bone and joint infections: an analysis of success rates, treatment modalities and safety.

ABSTRACT: Bone and joint infections are difficult to treat, and increasing antibiotic resistance has only made them more challenging. This has led to renewed interest in phage therapy (PT). The aim of this systematic review was to determine success rate, current treatment modalities and safety of PT in bone and joint infections.A systematic search of PubMed, EMBASE and Cochrane databases as well as the journal PHAGE for literature published between January 2000 and April 2021 was conducted according to PRISMA guidelines to identify all human studies assessing bacteriophages as therapy for bone and joint infections. All study designs and patient populations were eligible. The review's primary outcome was success rate.Twenty records describing a total of 51 patients and 52 treatment episodes we

SUBMITTER: Geneviere J 

PROVIDER: S-EPMC8722473 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature