Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.

ABSTRACT: On the 24 ^th November 2021 the sequence of a new SARS CoV-2 viral isolate spreading rapidly in Southern Africa was announced, containing far more mutations in Spike (S) than previously reported variants. Neutralization titres of Omicron by sera from vaccinees and convalescent subjects infected with early pandemic as well as Alpha, Beta, Gamma, Delta are substantially reduced or fail to neutralize. Titres against Omicron are boosted by third vaccine doses and are high in cases both vaccinated and infected by Delta. Mutations in Omicron knock out or substantially reduce neutralization by most of a large panel of potent monoclonal antibodies and antibodies under commercial development. Omicron S has structural changes from earlier viruses, combining mutations conferring tight bindi

SUBMITTER: Dejnirattisai W 

PROVIDER: S-EPMC8722586 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature