Omicron infection of vaccinated individuals enhances neutralizing immunity against the Delta variant.

ABSTRACT: Omicron variant (B.1.1.529) infections are rapidly expanding worldwide, often in settings where the Delta variant (B.1.617.2) was dominant. We investigated whether neutralizing immunity elicited by Omicron infection would also neutralize the Delta variant and the role of prior vaccination. We enrolled 23 South African participants infected with Omicron a median of 5 days post-symptoms onset (study baseline) with a last follow-up sample taken a median of 23 days post-symptoms onset. Ten participants were breakthrough cases vaccinated with Pfizer BNT162b2 or Johnson and Johnson Ad26.CoV2.S. In vaccinated participants, neutralization of Omicron increased from a geometric mean titer (GMT) FRNT₅₀ of 28 to 378 (13.7-fold). Unvaccinated participants had similar Omicron neutralization a

SUBMITTER: Khan K 

PROVIDER: S-EPMC8722619 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature