TRNA biogenesis and specific aminoacyl-tRNA synthetases regulate senescence stability under the control of mTOR.

ABSTRACT: Oncogenes or chemotherapy treatments trigger the induction of suppressive pathways such as apoptosis or senescence. Senescence was initially defined as a definitive arrest of cell proliferation but recent results have shown that this mechanism is also associated with cancer progression and chemotherapy resistance. Senescence is therefore much more heterogeneous than initially thought. How this response varies is not really understood, it has been proposed that its outcome relies on the secretome of senescent cells and on the maintenance of their epigenetic marks. Using experimental models of senescence escape, we now described that the stability of this proliferative arrest relies on specific tRNAs and aminoacyl-tRNA synthetases. Following chemotherapy treatment, the DNA binding of the typ

SUBMITTER: Guillon J 

PROVIDER: S-EPMC8722728 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature