RNA Solutions: Synthesizing Information to Support Transcriptomics (RNASSIST).

ABSTRACT:

Motivation

Transcriptomics is a common approach to identify changes in gene expression induced by a disease state. Standard transcriptomic analyses consider differentially expressed genes (DEGs) as indicative of disease states so only a few genes would be treated as signals when the effect size is small, such as in brain tissue. For tissue with small effect sizes, if the DEGs do not belong to a pathway known to be involved in the disease, there would be little left in the transcriptome for researchers to follow up with.

Results

We developed RNA Solutions: Synthesizing Information to Support Transcriptomics (RNASSIST), a new approach to identify hidden signals in transcriptomic data by linking differential expression and co-expression networks using machine learning. We appli

SUBMITTER: Chen YP 

PROVIDER: S-EPMC8723147 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature